MersV1, Main, Exploration, bibRecord, 000A90

A code for transcription elongation speed.

Identifieur interne : 000A90 ( Main/Exploration ); précédent : 000A89; suivant : 000A91

A code for transcription elongation speed.

Auteurs : Eyal Cohen [Israël] ; Zohar Zafrir [Israël] ; Tamir Tuller [Israël]

Source :

RNA biology [ 1555-8584 ] ; 2018.

RBID : pubmed:29165040

Descripteurs français

KwdFr :
- ARN messager (génétique), Aptitude génétique, Codon (génétique), DNA-directed RNA polymerases (génétique), Escherichia coli (génétique), Ribosomes (génétique), Transcription génétique, Élongation de la traduction.
MESH :
- génétique : ARN messager, Codon, DNA-directed RNA polymerases, Escherichia coli, Ribosomes.
- Aptitude génétique, Transcription génétique, Élongation de la traduction.

English descriptors

KwdEn :
- Codon (genetics), DNA-Directed RNA Polymerases (genetics), Escherichia coli (genetics), Genetic Fitness, Peptide Chain Elongation, Translational, RNA, Messenger (genetics), Ribosomes (genetics), Transcription, Genetic.
MESH :
- chemical , genetics : Codon, DNA-Directed RNA Polymerases, RNA, Messenger.
- genetics : Escherichia coli, Ribosomes.
- Genetic Fitness, Peptide Chain Elongation, Translational, Transcription, Genetic.

Abstract

The two major steps of gene expression are transcription and translation. While hundreds of studies regarding the effect of sequence features on the translation elongation process have been published, very few connect sequence features to the transcription elongation rate. We suggest, for the first time, that short transcript sub-sequences have a typical effect on RNA polymerase (RNAP) speed: we show that nucleotide 5-mers tend to have typical RNAP speed (or transcription rate), which is consistent along different parts of genes and among different groups of genes with high correlation. We also demonstrate that relative RNAP speed correlates with mRNA levels of endogenous and heterologous genes. Furthermore, we show that the estimated transcription and translation elongation rates correlate in endogenous genes. Finally, we demonstrate that our results are consistent for different high resolution experimental measurements of RNAP densities. These results suggest for the first time that transcription elongation is partly encoded in the transcript, affected by the codon-usage, and optimized by evolution with a significant effect on gene expression and organismal fitness.

DOI: 10.1080/15476286.2017.1384118
PubMed: 29165040

Affiliations:

Israël

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en">A code for transcription elongation speed.</title>
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<affiliation wicri:level="1"><nlm:affiliation>a Balavatnick School of Computer Science , Tel Aviv University , Tel Aviv , Israel.</nlm:affiliation>
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<country xml:lang="fr">Israël</country>
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<series><title level="j">RNA biology</title>
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<term>Escherichia coli (genetics)</term>
<term>Genetic Fitness</term>
<term>Peptide Chain Elongation, Translational</term>
<term>RNA, Messenger (genetics)</term>
<term>Ribosomes (genetics)</term>
<term>Transcription, Genetic</term>
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<term>Ribosomes (génétique)</term>
<term>Transcription génétique</term>
<term>Élongation de la traduction</term>
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<term>Escherichia coli</term>
<term>Ribosomes</term>
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<term>Peptide Chain Elongation, Translational</term>
<term>Transcription, Genetic</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Aptitude génétique</term>
<term>Transcription génétique</term>
<term>Élongation de la traduction</term>
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<front><div type="abstract" xml:lang="en">The two major steps of gene expression are transcription and translation. While hundreds of studies regarding the effect of sequence features on the translation elongation process have been published, very few connect sequence features to the transcription elongation rate. We suggest, for the first time, that short transcript sub-sequences have a typical effect on RNA polymerase (RNAP) speed: we show that nucleotide 5-mers tend to have typical RNAP speed (or transcription rate), which is consistent along different parts of genes and among different groups of genes with high correlation. We also demonstrate that relative RNAP speed correlates with mRNA levels of endogenous and heterologous genes. Furthermore, we show that the estimated transcription and translation elongation rates correlate in endogenous genes. Finally, we demonstrate that our results are consistent for different high resolution experimental measurements of RNAP densities. These results suggest for the first time that transcription elongation is partly encoded in the transcript, affected by the codon-usage, and optimized by evolution with a significant effect on gene expression and organismal fitness.</div>
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Serveur d'exploration MERS

A code for transcription elongation speed.

A code for transcription elongation speed.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration MERS
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